L.A. doctor claims cure for late stage COVID-19 infection

For T rump lovers, note that this info is coming to you via a progressive liberal Democrat, who loves Obama.

https://abc7news.com/coronavirus-drug-covid-19-malaria-hydroxychloroquine/6079864/

Dr. Anthony Cardillo proclaims that he has treated several patients with Hydroxychloroquine PLUS Zinc with severe cases of COVID-19, and they were ALL fine within 8-10 hrs.

He declares that he has found it only works if combined with zinc. The drug, (hydroxychloroquine) he said, opens a channel for the zinc to enter the cell and block virus replication.

If other treating physicians follow this protocol and get similar results, we may not need to wait for the scientific studies to be completed to start seeing major results.

If this report turns out to be for real, then I will have to eat crow for making fun of our dipshit DOTUS for his undying hunch about the malaria medicine.

Seems too good to be true, but it’s worth studying.

Ya think? I am wondering why that doctor and his claims are not all over the net and the news.

I mean if it’s for real it would mean many lives could be saved and the economy could soon be on the way to the end of the tunnel.

 

What are Dr. Anthony Cardillo's Specialties?

Emergency Medicine

Emergency medicine specialists diagnose and treat patients with life-threatening conditions like heart attack, drug overdose, shock, or massive bleeding.


Alrightie, at least he’s not a kook. We shall see. Good luck.

Still nothing on the broader news system about this possible cure that could help bring the world out of the worst of the pandemic and get economies going again.

Huh. You would think with that kind of upside, this would be widespread news, if it had a hint of being for real. But these days, expecting things to follow a logical course, is perhaps a fool’s expectation.

I dug this up on the web:

https://www.youtube.com/watch?v=BIymfznD7YA

It shows how hydroxychloroquine can act as an “ionophore” which allows Zinc to get thru the cell wall and thus enabling it to block the reproduction of viral RNA.

Again, I am concerned that this video is from weeks ago, and the knowledge was weeks old, even then.

If this is for real, then a lot of people have died, perhaps needlessly, while this information remains out of the zeitgeist.

The devil is in the details. Perhaps that’s one reason doctors and scientists take so much time rolling out new drugs and applications.

Being an expert doesn’t mean being perfect, but it sure does stack the odds in one’s favor.

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182877/

Hydroxychloroquine Update For April 6 By Derek Lowe 6 April, 2020

https://blogs.sciencemag.org/pipeline/archives/2020/04/06/hydroxychloroquine-update-for-april-6

There’s a lot of news to catch up on, and to keep things straight I’ll divide the hydroxychloroquine part out into this post, and cover others in the next one. My previous reviews of the clinical data in this area are here.

First up is this study from France. It’s another very small one, and all the usual warnings apply because of that. It’s from a team at the University of Paris and Saint-Louis Hospital there, and they evaluated 11 consecutive patients admitted there with the same course of treatment as the Marseilles group first reported (hydroxychloroquine 600mg/day and azithromycin, 500mg the first day and 250 mg/day thereafter). The mean age of their patients was 58.7 years, and (notably) 8 of the 11 had significant comorbidities (two obese, 5 with various forms of cancer, one with HIV). That’s a tough population, and unfortunately, the HCQ/AZ combination did nothing. One patient died (and two others went on to the ICU) and of the ten remaining, 8 were still positive for the virus by nasal swab on days 5/6 after treatment. One patient had to discontinue therapy on day 4 because of QT prolongation, a known side effect of hydroxychloroquine that can lead to fatal heart arrhythmia.

So while this is a small study and not a perfect match, it provides no evidence to show that the HCQ/AZ combination had any benefit at all. While we’re on the subject of QT prolongation …


Tim, I bet you’ll find this article fascinating:

Chloroquine, Past and Present By Derek Lowe 20 March, 2020

https://blogs.sciencemag.org/pipeline/archives/2020/03/20/chloroquine-past-and-present

Now that chloroquine is in the news everywhere, I thought it might be interesting to have a closer look at the compound. The first part of this post will be chemistry-heavy, further down we’ll get into the pharmacology and medical uses.

Chloroquine’s fame is as an antimalarial drug, and the history of antimalarials starts of course with quinine (at right). …

But it still can lead to depression and other effects. Hydroxychloroquine came along in the 1950s, and just has an extra OH group coming off of one of those N-ethyls over at the end of the chain; it’s quite similar to chloroquine itself.

You might wonder how an antiparasitical drug might do that, but the problem is that the mode of action of all these drugs against malaria parasites is still being argued over. And there are almost certainly several modes of action at work, which will go on to have different effects in different human tissues, etc. Both chloroquine and hydroxychloroquine are used off-label for rheumatoid arthritis and for lupus, but how they work in these areas is another shoulder-shrugger, and there are side effects in the eye. It’s been suggested as an adjunct in some cancer therapy regimes, but there are problems there, too, in the kidney. …

189 comments on “Chloroquine, Past and Present” (from looking at the first dozen or two, seems like a well moderated constructive comments section.)

It was a small group and therefore it will need further study with a larger group. Just hope it’s not another Tuskegee, because that won’t work either.

Thanks for the info. But this claim by this ER doc, is not about Hydrochloroquine plus Z-pac (azithromycin). It is about Hydrochloroquine plus Zinc.

The addition of the Z-pac only makes sense to me if the patient is also suffering from a bacterial infection. Useless if there is no bacterial infection. In fact maybe worse than useless, since it kills off good bacteria.

But it does make sense to me that the hydrochloroquine (which is a known immune system modulator) might calm a cytokine storm that has antibodies going nuts and destroying everything in its path, including lung tissue, then perhaps as the doc claims the Zinc can then block the virus from invading further cells.

It may turn out to be a statistical fluke and all the people that he was treating were going to have a miraculous improvement in 8-10 hrs even without the hydrochloroquin plus Zinc.

But that seems unlikely to me.

Still if this is a potential cure, how come it is not getting more attention?