I’ve already shown how you guys are mistaken here.
1 Like
Actually, you are a mammal, or more specifically a primate, admittedly one with an amazing brain, still you are an evolved animals, a product of billions of years worth of Earth’s evolution.
You could say our biosphere and circumstance “programs” us, but that doesn’t do it justice.
Well okay you’ve proven that to your own satisfaction, still, you’ve yet to explain what you are, or who you are?
Nor have you answered: how it is that you can dodge that ball that’s suddenly flying at your face?
[quote=“citizenschallengev4, post:99, topic:10083”]
Okay, A theory of microtubule catastrophes and their regulation
Okay write, I looked it up. First thing I learned was this microtubule catastrophe is,(A) Dynamic instability, in which abrupt transitions occur between growing and shrinking states, is an intrinsic property of microtubules that is regulated by both mechanics and specialized proteins.
Not quite.
What diseases are caused by malfunction of microtubules?
Neurodegeneration and microtubule dynamics: death by a thousand cuts
Microtubule dynamics, the process of interconversion between stable and dynamic pools, and the proportions of these two pools have the potential to influence a wide variety of cellular processes. Reduced microtubule stability has been observed in several neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic Lateral Sclerosis (ALS), and tauopathies like Progressive Supranuclear Palsy.
Hyperstable microtubules, as seen in Hereditary Spastic Paraplegia (HSP), also lead to neurodegeneration. Therefore, the ratio of stable and dynamic microtubules is likely to be important for neuronal function and perturbation in microtubule dynamics might contribute to disease progression.
Meaning it’s part of normal function, not a literal massive destructive event. Going through that study, best I could, I found no mention of microtubule’s influence on brain process speeds.
Microtubule catastrophe: an aging process
A microtubule “catastrophe” event manifests itself by the sudden switch of a growing microtubule into a rapidly shortening state. The widely accepted view of microtubule catastrophe is that it involves a single random event, such as the sudden loss of a protective end structure [[1]
The finding that young microtubules are less likely to undergo catastrophe means that microtubules age: catastrophe frequency is not a constant, but rather increases with time.
And that perfectly describes the gradual deterioration of mental capacity as 100 trillion microtubules, connected by 1000 trillion synapses, suffer a gradually increasing
rate of catastrophe without rescue, gradually diminishing the enormous MT field and data processing capacity.
You are talking about decline. He is talking about normal function. He is talking about perception. You are talking about information processing.
1 Like
Microtubules form important cytoskeletal structures that play a role in establishing and maintaining neuronal polarity, regulating neuronal morphology, transporting cargo, and scaffolding signaling molecules to form signaling hubs. Within a neuronal cell, microtubules are found to have variable lengths and can be both stable and dynamic. Microtubule associated proteins, post-translational modifications of tubulin subunits, microtubule severing enzymes, and signaling molecules are all known to influence both stable and dynamic pools of microtubules. Microtubule dynamics, the process of interconversion between stable and dynamic pools, and the proportions of these two pools have the potential to influence a wide variety of cellular processes. Reduced microtubule stability has been observed in several neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic Lateral Sclerosis (ALS), and tauopathies like Progressive Supranuclear Palsy. Hyperstable microtubules, as seen in Hereditary Spastic Paraplegia (HSP), also lead to neurodegeneration. Therefore, the ratio of stable and dynamic microtubules is likely to be important for neuronal function and perturbation in microtubule dynamics might contribute to disease progression.
Write, this description is a far cry from your claims.
That is all I’m trying to get across to you.
Can I get a translation of the sentence in bold? What cargo are they transporting? What is neuronal polarity and morphology?
A marxist materialist take on this where the commodification of life and the promotion of individualism under capitalism leads to nihilism
No, you are reacting to the term “catastrophe”, as a large destructive event.
I have told you before that MT are dynamic and able to grow and shrink as necessary.
The shrinkage is caused by catastrophe. If there is no rescue the MT will be impaired.
According to Hameroff when microtubules undergo a Tau related MT catastrophe, that becomes continued disintegration of the microtubule.
let’s trace it.
Ill start with how a MT grows.
Summary
Non-centrosomal microtubule bundles play important roles in cellular organization and function. Although many diverse proteins are known that can bundle microtubules, biochemical mechanisms by which cells could locally control the nucleation and formation of microtubule bundles are understudied. Here, we demonstrate that the concentration of tubulin into a condensed, liquid-like compartment composed of the unstructured neuronal [protein tau]
Tau Protein - an overview | ScienceDirect Topics) is sufficient to nucleate microtubule bundles. We show that, under conditions of macro-molecular crowding, tau forms liquid-like drops. Tubulin partitions into these drops, efficiently increasing tubulin concentration and driving the nucleation of microtubules. These growing microtubules form bundles, which deform the drops while remaining enclosed by diffusible tau molecules exhibiting a liquid-like behavior. Our data suggest that condensed compartments of microtubule bundling proteins could promote the local formation of microtubule bundles in neurons by acting as non-centrosomal microtubule nucleation centers and that liquid-like tau encapsulation could provide both stability and plasticity to long axonal microtubule bundles.
Graphical Abstract
How is this related to this topic? I mean actually, not because MT are the basis of everything. I mean to the topic that inthedarkness is discussing.
You should check out the Vervaeke thread. I think you are missing an entire part of being human. We are born with curiosity and desires. We aren’t told to learn, we have some sort of innate need for that. We can’t form ideas about what is true until things have meaning. We can’t have meaning before we have sense of what is relevant and what is not. There are so many things coming at our senses that it’s not possible that someone else is programming us to make those decisions. Society wouldn’t exist if our ape-like ancestors did not have feelings for their children.
If what you say is true, you should be able to trace the things you talk about, like “society pushing” or “being programmed”. If I have nothing to call my own, then who does, and why would they push me in any direction?
Sorry, I was working on another post about microtubules and put it in this thread by mistake.
Can you move it to my Microtubule thread?
Seems like an irrelevant detail. That point is that nothing you feel is your own but only because society says that’s how you ought to react given certain circumstances. That’s everyone’s life. So it’s effectively a robot.
Not everyone is born with that.
If you didn’t have the influence of society you wouldn’t want what you want and think what is good or bad is such. I wouldn’t like the things I like if society didn’t push them on me, same with anything else.
The only “right” way to be in the world is to exist without feeling inherently joyful or sad over anything.
Even if everything else you said had merit, this would be a terrible conclusion. You can’t turn off feelings. You can try, but you’ll just change your feelings. Maybe this society you speak of wants you to shut down and tricked you into it. You set your own trap and stepped into it.
Which is a benefit to understanding your animal nature.
Appreciating that you can’t turn off feelings, accept them, work with them.
Take advantage of the Free Won’t we human animals have developed.
If you are less than perfect, you don’t have to beat yourself,
because you know in the end you are what you are.
That doesn’t put an end to curiosity, or striving, but it does get it into a healthier perspective.
=======================
Not at all, that’s why I added that quote.
And right, the “catastrophe” is part of the weird building process moving forwards and backwards, with age that dynamic probably gets sloppier. It gets complicated.
It would be fun to find out who coined such an odd term and what they were thinking, seems most inappropriate, even worse than the “hallucination” thing.
neuronal polarity
Neuronal Polarity: Positive and Negative Feedback Signals
Cell polarization is a crucial step in multiple cellular aspects such as differentiation, morphogenesis, and migration. Among the various cell types, neurons are highly polarized cells that have a long axon, and several short dendrites. These two different processes generate the information flow that is essential for brain functions such as memory, learning, and emotion.
Establishment and maintenance of neuronal polarity are critical for neuronal development and function. One of the fundamental questions in neurodevelopment is how neurons generate only one axon and several dendrites from multiple minor neurites.
Definition. Neuronal polarity is the asymmetry in the distribution of cellular components (cellular polarity) within Neurons .
What cargo are they transporting?
Microtubules provide long tracks along which a broad range of organelles and vesicles are transported by kinesin and dynein motors. Motor protein complexes also tether cargoes to cytoskeletal filaments, helping facilitate their interaction and communication. The generation of biochemically distinct microtubule subpopulations allows subsets of motors to recognize a given microtubule identity, allowing further organization within the cytoplasm. Both transport and tethering are spatiotemporally regulated through multiple modes, including acute modification of both motor–cargo and motor–track associations by various physiological signals. Strict regulation of intracellular transport is particularly important in specialized cell types such as neurons. Here, we review general mechanisms by which cargo transport is controlled and also highlight examples of transport regulated by multiple mechanisms.
Understand the Functions of Scaffold Proteins in Cell Signaling by a Mesoscopic Simulation Method
Abstract
Scaffold proteins are central players in regulating the spatial-temporal organization of many important signaling pathways in cells. They offer physical platforms to downstream signaling proteins so that their transient interactions in a crowded and heterogeneous environment of cytosol can be greatly facilitated.
Yeah. Anything I read about MT leads me to more terms that I need to research. I would need to be a neuroscientist to know what effect they have
1 Like
I know the feeling.
It does get overwhelming.
I’ve been reading up on them long before becoming familiar with Write’s passion - though I’d never pretend to have more than a rough outline, but I do have that much.
That’s why I tag Write so often because he says things and makes connections, that I don’t see echoed in the papers, even the one’s he shares.
Hammeroff is a scientific outlier and not at the core of MT studies, and until I see his claims echoed in other’s papers, I’ll remain the skeptical eye.
.
.
*
1 Like
The more I learn about MT, the greater the wonderous potentials contained in this little dipolar coil. Apparently it has no limits in processing information over long distances as well by inter- and intra- cellular communication.
The entire neural/cellular network, masterminded by the self-referential control mechanism in the brain, appears to sort and amplify electro-chemical information, i.e. vision, hearing, etc. and the manufacturing of (re-)“action potentials” that allow us to “act”.
Description
Neural connections concept. Human body neurology, nervous system. 3D illustrationNeural connections concept. Human body neurology, nervous system. 3D illustration
Neural Connections Concept Human Body Neurology Nervous System 3d Illustration Stock Photo - Download Image Now - iStock
The human biome is a self-referential dynamic local field in the spacetime fabric.
Are we the multiverse ? That would be ironic.
No. We are not. I wish the forum would just let me give the one word answer, because that’s all that is needed here.
2 Likes
And that is the question Tegmark poses. If you were a simulation, how would you know?