Microtubules the seat of Consciousness

Hey, check it out, our body is full of surprises.

Those folds within folds of cumulative harmonic complexity flowing down the stream of time.

Never Before Seen Viral Organisms Found Inside Our Bodies - “Obelisks”

Anton Petrov

Hello and welcome! My name is Anton and in this video, we will talk about strange new organisms discovered inside our bodies referred to as ‘obelisks’

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To a virus the human biome is a universe all to itself.

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Let’s go a little deeper and get a taste of what I believe ORCH-OR is based on and why Roger Penrose became interested in cellular molecular “communication” and “chemical reaction” via microtubules because their bipolarity makes them sensitive to magnetic fields.
This excellent conversational video explains and depicts quantum brain activity in birds, migrating via “reading” the earth’s magnet fields.

and the science involved

Radical pairs may play a role in microtubule reorganization

Scientific Reports volume 12, Article number: 6109 (2022) Cite this article

Abstract

> The exact mechanism behind general anesthesia remains an open question in neuroscience. It has been proposed that anesthetics selectively prevent consciousness and memory via acting on microtubules (MTs).

It is known that the magnetic field modulates MT organization. A recent study shows that a radical pair model can explain the isotope effect in xenon-induced anesthesia and predicts magnetic field effects on anesthetic potency. Further, reactive oxygen species are also implicated in MT stability and anesthesia.

> Based on a simple radical pair mechanism model and a simple mathematical model of MT organization, we show that magnetic fields can modulate spin dynamics of naturally occurring radical pairs in MT. We propose that the spin dynamics influence a rate in the reaction cycle, which translates into a change in the MT density. We can reproduce magnetic field effects on the MT concentration that have been observed. Our model also predicts additional effects at slightly higher fields.

Our model further predicts that the effect of zinc on the MT density exhibits isotopic dependence. The findings of this work make a connection between microtubule-based and radical pair-based quantum theories of consciousness.

https://www.nature.com/articles/s41598-022-10068-4

Abstract

The exact mechanism behind general anesthesia remains an open question in neuroscience. It has been proposed that anesthetics selectively prevent consciousness and memory via acting on microtubules (MTs). It is known that the magnetic field modulates MT organization. A recent study shows that a radical pair model can explain the isotope effect in xenon-induced anesthesia and predicts magnetic field effects on anesthetic potency. Further, reactive oxygen species are also implicated in MT stability and anesthesia. Based on a simple radical pair mechanism model and a simple mathematical model of MT organization, we show that magnetic fields can modulate spin dynamics of naturally occurring radical pairs in MT. We propose that the spin dynamics influence a rate in the reaction cycle, which translates into a change in the MT density. We can reproduce magnetic field effects on the MT concentration that have been observed. Our model also predicts additional effects at slightly higher fields. Our model further predicts that the effect of zinc on the MT density exhibits isotopic dependence.

The findings of this work make a connection between microtubule-based and radical pair-based quantum theories of consciousness.

So, the suggestion is that, consciousness is based on magnetic fields?

The video was great, it’s fun seeing how they keep getting closer to understanding mysterious aspects of bird navigation.

But, a sensing organ that is fine tuned to deciphering our Earth’s magnetic fields, is a far cry from a creature interacting with a rapidly changing macroscopic physical reality to produce awareness of what’s going on around them.

I’ll remain extremely skeptical of claims regarding origins/structure of human consciousness that ignore the environmental space (and happenings within that space) that our body exists within.

Quantum is a pizazz word. What I find interesting is that I don’t think anything happens with atoms that isn’t Quantum in nature. So what else would they be expecting to see. I mean what would a non-quantum interaction look like?
:v:

[quote=“citizenschallengev4, post:205, topic:9472”]
So, the suggestion is that, consciousness is based on magnetic fields?

No, it suggests that some conscious animals can navigate the earth’s magnetic fields via microtubule orientation, similar to the needle in a compass pointing north.
Apparently these dedicated MTs are located in the optical sensory network and “tell” the brain of changes in the earth’s magnetic field by which they can consciously navigate.

[quote=“citizenschallengev4, post:205, topic:9472”]
Quantum is a pizazz word. What I find interesting is that I don’t think anything happens with atoms that isn’t Quantum in nature. So what else would they be expecting to see. I mean what would a non-quantum interaction look like?>

I agree. And that perspective also suggests that consciousness resides at quantum level and that is one reason why it is so difficult to define or test.

Interestingly, at quantum levels the “observer” effect becomes a factor.

Magnetoreception in birds

[Roswitha Wiltschko] and Wolfgang Wiltschko

Published:04 September 2019https://doi.org/10.1098/rsif.2019.0295

Abstract

Birds can use two kinds of information from the geomagnetic field for navigation: the direction of the field lines as a compass and probably magnetic intensity as a component of the navigational ‘map’.

The direction of the magnetic field appears to be sensed via radical pair processes in the eyes, with the crucial radical pairs formed by cryptochrome. It is transmitted by the optic nerve to the brain, where parts of the visual system seem to process the respective information. Magnetic intensity appears to be perceived by magnetite-based receptors in the beak region; the information is transmitted by the ophthalmic branch of the trigeminal nerve to the trigeminal ganglion and the trigeminal brainstem nuclei.

Yet in spite of considerable progress in recent years, many details are still unclear, among them details of the radical pair processes and their transformation into a nervous signal, the precise location of the magnetite-based receptors and the centres in the brain where magnetic information is combined with other navigational information for the navigational processes.
More … https://royalsocietypublishing.org/doi/10.1098/rsif.2019.0295#
.

Continuing our research on the state of science about microtubules.

Recent Approaches to the Identification of Novel Microtubule-Targeting Agents

Consistent with their involvement in core cellular processes, affecting microtubule assembly results in cytotoxicity and cell death. For these reasons, microtubules are among the most important targets for the therapeutic treatment of several diseases, including cancer.

The vast literature related to microtubule stabilizers and destabilizers has been reviewed extensively in recent years. Here we summarize recent experimental and computational approaches for the identification of novel tubulin modulators and delivery strategies. These include orphan small molecules, PROTACs as well as light-sensitive compounds that can be activated with high spatio-temporal accuracy and that represent promising tools for precision-targeted chemotherapy.

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@ CC

In context of your evolving body-mind concept, I came up with a term that IMO describes the body-mind functions from the perspective of the evolved advantageous survival strategies that form the variety of abilities and adaptations of “integrated” systems.

Where the body is the evolved dynamic system that functions as the vehicle that is driven by an independently evolved brain that is in control of the vehicle.

What do you think of the concept that where the brain is formally fully and consciously intelligent, the body is sensory sub-consciously quasi-intelligent and together (connected by the spinal chord) they make use of the most efficient way of dealing with survival mechanisms that allows natural selection to evolve biological patterns into the incredible variety we are witnessing today.

This is but one example

Estimating the total amount of life on Earth

Life on Earth remains a subject of immense curiosity and scientific investigation across all sections of humanity. But have you ever stopped to think about the total amount of life that has existed on Earth since the first cells appeared 3.8 billion years ago?

Crockford’s team found that land plants, despite their late emergence, have likely been the biggest contributors to Earth’s primary production.

Cyanobacteria also stand out as significant contributors. This research is vital in understanding not just the amount of primary production but also the organisms responsible for it.

One fascinating aspect of the study is the estimation of life on Earth, both historically and presently. By correlating primary production with cell existence, the researchers approximate that around 10^30 (10 noninillion) cells exist today.

Throughout Earth’s history, between 10^39 (a duodecillion) and 10^40 cells have likely existed.

These combinations of several combined individual “survival” functions and strategies at all levels of evolved intelligence, compose the “individual” in living organisms and allow for an infinite variety of adaptions of those survival systems.

Care to comment?

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That sounds pretty spot on.

I like it, and could never have come up with that formulation.
I’ll be chewing on those words.
This is exactly why I’m so desperate for serious feedback.

Thanks. :raising_hand_man:

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Also the learning and remembering new lessons to build upon.

Because that changing “vehicle” learns from novel ways moving and interactions with environment,
which created novel circumstance, challenges, and never ending novelty,
thus the learning curve was born,
which in time keeps getting “improved” upon, according to changing physical conditions.

And so on.

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An interesting article that explains the advantage of consciousness over and above the ability of an organism to react unconsciously to stimulus.

What is consciousness for?

Abstract

The answer to the title question is, in a word, volition. Our hypothesis is that the ultimate adaptive function of consciousness is to make volitional movement possible. All conscious processes exist to subserve that ultimate function. Thus, we believe that all conscious organisms possess at least some volitional capability.

Consciousness makes volitional attention possible; volitional attention, in turn, makes volitional movement possible. There is, as far as we know, no valid theoretical argument or convincing empirical evidence that consciousness itself has any direct causal efficacy other than volition.

Consciousness, via volitional action, increases the likelihood that an organism will direct its attention, and ultimately its movements, to whatever is most important for its survival and reproduction.

https://www.sciencedirect.com/science/article/pii/S0732118X15300039#

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